Optimal Conditions for Clostridium difficile Toxins Production
نویسندگان
چکیده
منابع مشابه
Toxins A and B of Clostridium difficile.
The toxins produced by Clostridium difficile share several functional properties with other bacterial toxins, like the heat-labile enterotoxin of Escherichia coli and cholera toxin. However, functional and structural differences also exist. Like cholera toxin, their main target is the disruption of the microfilaments in the cell. However, since these effects are not reversible, as found with ch...
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Clostridium difficile is a significant problem in hospital settings as the most common cause of nosocomial diarrhea worldwide. C. difficile infections (CDIs) are characterized by an acute intestinal inflammatory response with neutrophil infiltration. These symptoms are primarily caused by the glucosylating toxins, TcdA and TcdB. In the past decade, the frequency and severity of CDIs have increa...
متن کاملThe Enterotoxicity of Clostridium difficile Toxins
The major virulence factors of Clostridium difficile infection (CDI) are two large exotoxins A (TcdA) and B (TcdB). However, our understanding of the specific roles of these toxins in CDI is still evolving. It is now accepted that both toxins are enterotoxic and proinflammatory in the human intestine. Both purified TcdA and TcdB are capable of inducing the pathophysiology of CDI, although most ...
متن کاملClostridium difficile toxins and severe C. difficile infection.
The pathogenesis of colitis due to Clostridium difficile is closely linked to the elaboration of 2 large, single-unit glucosyltransferases referred to as toxin A (TcdA) and toxin B (TcdB). Clinical isolates from patients with symptomatic C. difficile infection (CDI) invariably produce both TcdA and TcdB or TcdB alone. Vaccination of experimental hamsters against both toxins prevents fatal C. di...
متن کاملOverlapping roles for toxins in Clostridium difficile infection.
All bacterial infections are of great concern to society. Some bacterial infections, however, seem to have periods of high drama or wider public health import. The 100 or so known species of Clostridium (from the Greek kloster or “spindle”; phylum Firmicutes) belong to a group of obligately anaerobic, gram-positive, spore-forming, rod-shaped bacteria. Of these, only a handful are pathogenic to ...
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ژورنال
عنوان ژورنال: International Journal of Current Microbiology and Applied Sciences
سال: 2020
ISSN: 2319-7692,2319-7706
DOI: 10.20546/ijcmas.2020.910.400